From record investment rounds to new acellular product launches, 2021 was a historic year for the cellular agriculture field. With new partnerships and advancements, the field made progress toward becoming part of a viable future of food system.
Following all the incredible breakthroughs and progress last year, it was important for the cellular agriculture field to continue its momentum into 2022. And the field is already off to a great start.
From new investments and acquisitions to a range of new partnerships, we look at what happened this January 2022 in cellular agriculture.
To start the year, cellular agriculture startup Remilk raised a massive $120 million in Series B funding to produce animal-free dairy products. By designing microorganisms to produce the same dairy ingredients found in cow’s milk, Remilk aims to make the same dairy products without requiring the cow.
Remilk’s funding round was led by Hanaco Ventures. The Series B financing also featured investments from Rage Capital, CPT Capital, and dairy companies Tnuva and Hochland. The funding round brings Remilk’s total investments raised to $131.3 million. The company previously raised $11.3 million in Series A funding in December 2020.
The largest funding round for an acellular agriculture (also known as precision fermentation) startup in Asia, Remilk’s Series B round more than doubles all funding for non-meat cellular agriculture startups across the continent. Remilk’s funding round is also the second-largest funding round to date in Asia, following Future Meat Technologies’ Series B round of $347 million in December 2021.
Japanese cell-based meat company IntegriCulture announced the company raised an additional $7 million in new funding to scale its cellular agriculture production platform. Investors in IntegriCulture’s funding round include AgFunder, Beyond Next Ventures, Real Tech Fund, and Future Food Fund.
Along with developing its own cell-based meat products, IntegriCulture aims to create a universal cellular agriculture platform for other companies in the field to scale production. Called the CulNet System, IntegriCulture aims to empower companies worldwide to produce their cell-cultured products sustainably.
The funding round brings IntegriCulture’s total funding to $16.4 million. IntegriCulture previously raised its Series A funding round of $7.2 million in May 2020.
South Korean cell-based meat startup DaNAgreen raised ₩8 billion (approximately 6.7 million USD) in Series A funding. Based in Seoul, South Korea, DaNAgreen is a cell-cultured meat company that focuses on developing scaffolding and enabling technologies to develop cell-cultured meat.
DaNAgreen’s funding round featured investments from Lotte Ventures, Timewise Investment, and Pathfinder H. The funding round brings DaNAgreen’s total funding to ₩10 billion (approx. 7.9 million USD).
Having developed a cost-effective scaffolding system, DaNAgreen aims to use the funding round to build an automated production system to accelerate its commercialization efforts and reduce the cost of its cell culture media. The company aims to launch a cell-based meat product in 2024 using its tissue engineering platform with its plant-based scaffolding technology.
Cell-based meat company Upside Foods (formerly Memphis Meats) announced the acquisition of cell-cultured seafood startup Cultured Decadence.
Based in Madison, Wisconsin, Cultured Decadence is the first American startup focusing on using cellular agriculture to produce lobster meat. In April 2021, Cultured Decadence raised the largest pre-seed funding round to date for a cell-based meat and seafood startup.
According to the announcement, Upside Foods acquired Cultured Decadence for an undisclosed sum to add cell-cultured lobster meat to its portfolio. As part of the acquisition, Cultured Decadence will adopt the Upside Foods brand name and remain in Wisconsin. Cultured Decadence’s co-founders Ian Johnson and John Pattison will also join Upside Foods as directors.
The first cellular agriculture acquisition in the US, the acquisition signals Upside Foods’ plan to expand beyond cell-based chicken and meat into a broader range of seafood products. While Upside Foods has previously stated that the company is looking to develop seafood products, this is the company’s first announcement to date about the company’s seafood endeavors.
The first acquisition of the year, the announcement indicates that more cellular agriculture companies may look to acquire other startups as they look to explore different types of products. In August 2021, for example, Singapore-based startup Shiok Meats acquired Gaia Foods, the first cell-based meat startup in the region focusing on red meat, to expand beyond seafood.
In November 2021, meat corporate JBS acquired Spanish cell-based meat startup BioTech Foods in a $100 million plan to enter the cell-based meat field.
The acquisition marks a great start to the year for Upside Foods, following a strong end to 2021. In November, Upside Foods announced the opening of their new cell-based meat facility in California.
In addition, in December, Upside Foods shared that its cell culture media formulation is free of animal components and used it to produce prototypes of two popular food items: cell-cultured chicken nuggets and chicken hot dogs.
While many cell-based meat companies have promised that their cell-based meat will be indistinguishable from conventional meat, how would it compare in a taste test? To answer that, cell-based meat startup SuperMeat recently held a blind taste test at its test kitchen, The Chicken, with Master chef judge Michal Ansky.
After sampling both dishes in a professional taste testing event, Ansky incorrectly selected the cell-based chicken dish believing it was conventional chicken meat. Click here to watch the video of the event. SuperMeat first opened its test kitchen in November 2020 for customers to try its cell-cultured chicken burger.
Cell-cultured seafood company BlueNalu announced a new partnership with foodservice company Food & Life Companies to develop a supply chain for BlueNalu’s cell-cultured bluefin tuna and other sushi-grade seafood.
Based in Osaka, Japan, Food & Life Companies owns the largest number of sushi restaurants in Japan and operates more than 1,000 restaurants across East Asia and Southeast Asia. As part of the partnership, the two companies will work together on product development and marketing as well as support the development of a regulatory framework for cell-cultured seafood in Japan.
Considering the importance of partnerships to bring cell-cultured foods to market, BlueNalu has formed partnerships with traditional food players worldwide. In September 2021, BlueNalu previously partnered with Nomad Foods, Europe’s largest frozen food company.
Motif Foodworks announced a new extension of its partnership with Solar Biotech, a bioprocessing company designed to help foodtech startups scale production, at the end of January.
A spin-off from synthetic biology company Ginkgo Bioworks, Motif FoodWorks uses Ginkgo’s microbe platform to produce acellular animal proteins to complement the flavor and texture of plant-based products.
According to the announcement, Solar Biotech will support Motif FoodWork’s growth into new product areas with pilot-scale precision fermentation (also known as acellular agriculture) and downstream processing capacity.
Motif FoodWorks and Solar Biotech’s partnership first began in 2020 when Motif leveraged Solar Biotech’s technology platform to scale the production of its first product: an animal-free myoglobin protein. Branded as HEMAMI, Motif’s myoglobin product aims to mimic the flavors of cooked ground meat in fresh and frozen plant-based burgers, patties, and sausages.
Following regulatory approval of its HEMAMI product in December, it is promising to see Motif Foodworks continue its partnership with Solar Biotech as Motif looks to develop new cell-cultured protein products.
As more cellular agriculture companies look to scale production, it will be important for the field to partner with companies to increase their production capacity. In August 2021, for example, cell-cultured dairy startup TurtleTree Labs also announced a partnership with Solar Biotech to scale production and bring down the costs of its cell-based dairy products.
Tnuva Group, one of Israel’s largest food producers, announced a partnership with biotech company Pluristem Therapeutics to develop and produce cell-based meat in Israel. The new company will use Pluristem’s proprietary technology in the field of cultured meat, and Tnuva will invest $7.5 million, with the option to invest an additional $7.5 million over the following 12 months.
Tnuva will also provide the R&D platform to develop consumer products and receive preferred marketing rights in Israel for any new products. According to Pluristem, its proprietary 3D platform can cost-effectively produce high-quality cells. Tnuva previously invested in Remilk’s Series A and Series B funding rounds in December 2020 and January 2022, respectively.
Dutch cell-based meat company Mosa Meat published a research paper outlining how the company made its animal-free cell culture media formulation.
In the research paper, the Mosa Meat team demonstrated how the company developed an animal-free cell culture media formulation to differentiate its animal stem cells into muscle cells found in meat.
The cell culture media is the nutritious mixture that cells grow in, which includes the cell culture serum. The cell culture media provides all the nutrients and growth factors that cells may need to replicate or differentiate into another cell type. There are two main obstacles in scaling serum: its sourcing and price.
Developing an inexpensive and animal-free growth media for cell lines has once been described as the Holy Grail for cellular agriculture companies.
In many scientific labs, a common cell culture serum used to grow cells is fetal bovine serum. Not only would this still involve animal sourcing in the production process, but fetal bovine serum is also inconsistent from batch to batch and very costly. Animal-free serums have been developed for medical purposes, but the problem of costliness remains for scaling production.
As a result, many cell-based meat companies are working on developing their own cell culture media formulation to address this key scaling pain point. For example, both Upside Foods and CellMeat shared that the companies removed fetal bovine serum from their cell culture media formulations in December 2021.
Considering the discussion initiated about the feasibility of scaling cell-based meat production by an article written for The Counter in September 2021, it is promising to see Mosa Meat publish some of its work on developing its cell culture media formulation.
As more companies look to scale production, it will be interesting to see if other companies follow Mosa Meat’s lead and publish their findings.
In Finland, researchers from the Future Sustainability Food Systems research group and VTT Technical Research Centre conducted a life cycle assessment on cell-cultured egg white proteins to compare their environmental impact to conventional chicken egg white protein.
The researchers found that cell-cultured egg white proteins generally require more electricity than conventional livestock agriculture. As a result, the source of energy impacts its environmental impact. In addition, the researchers found that cell-cultured egg white protein production reduced land use by almost 90% and greenhouse gas emissions by 31-55%. The results concerning the impact of water use were less conclusive, as the researchers stated it was highly dependent on the location of cell-cultured egg production.
After growing the first piece of cell-based meat in outer space in October 2019, Aleph Farms will space again. The startup shared it will be part of the Rakia Mission, the first-ever all-private crew to visit the International Space Station (ISS).
While on the space station, astronauts will conduct innovative research designed for microgravity conditions on behalf of various organizations worldwide, including Aleph Farms. In addition, Aleph Farms shared the company will also work on its next space challenge: developing a system that produces its cell-based steaks on a 3-year-long mission.
This project was co-developed by Astreas and advanced to Phase 2 of NASA’s Deep Space Food Challenge. Aleph Farms first announced its space program, Aleph Zero, in October 2020 to mark the first anniversary of growing the first piece of meat in outer space.
Cell-cultured shrimps, anyone? Cell-based seafood company Shiok Meats shared its plans to launch its first product in 18 to 20 months in Singapore. While the price point of S$50 (US$37) per kilogram is much higher than conventional shrimp meat, that would still be a significant drop in price from its previous point.
According to the company, it currently costs S$1,000 to produce a kilogram of its cell-based shrimp and previously cost S$10,000 per kilogram approximately two years ago. As the company grows and scales production capacity, Shiok Meats will aim to reach the price point of between S$5 and S$10 in the next 5 to 7 years.
Cell-cultured oysters, anyone? New startup Pearlita Foods aims to use cellular agriculture to develop cell-cultured oysters. Founded by Nikita Michelsen and Joey Peters, the startup first aims to develop cell-cultured oysters from its headquarters in North Carolina. According to the company, oysters play a key role in supporting marine ecosystems through water filtration.
By cultivating oyster meat directly from cells, Pearlita Foods aims to reduce the burden on wild oyster populations. Pearlita Foods has raised early funding from Big Idea Ventures and Sustainable Food Ventures.
China’s Ministry of Agriculture and Rural Affairs published its 5-Year Agricultural Plan and, for the first time, included cell-cultured meat in its plan as part of its food security blueprint moving forward.
By looking into the technology, the strategic initiative may accelerate the country’s regulatory timeline for cell-cultured meat and drive more investment into the field. Two cell-based meat startups in Mainland China, Joes Future Food and CellX, both raised funding rounds in September 2021. Along with improving the environmental sustainability of our global food system, cellular agriculture can help China address its food security needs.
There are many questions about cultural acceptance that will still need to be explored for cell-based meat. For the world’s Jewish and Muslim populations, for example, it is yet to be determined whether cultured meat can be labeled as kosher or halal, respectively.
While Eat Just has consulted with religious experts, the company has not yet received any recognition for its cell-cultured meat as kosher or halal. Meanwhile, Israeli startup Future Meat Technologies recently shared that the company extracted its cell lines from animals slaughtered in a kosher manner. Ahmed Khan was previously interviewed on Green Queen to comment on how his view of how cell-based meat could qualify as halal.
To start the new year, KFC restaurants in the US will sell Beyond Meat’s plant-based chicken for a limited time. In addition, KFC shared that customers can buy its Beyond Fried Chicken in 6 or 12-piece orders, starting at $6.99. While pricier than KFC’s conventional fried chicken, it is notable that the price point of Beyond Meat’s product is almost on par with its prices. In July 2020, KFC first announced its plans to sell the plant-based Beyond Chicken at more than 50 locations in southern California following a pilot test in Atlanta, Georgia, in August 2019.
In February 2021, Beyond Meat signed a strategic partnership with Yum! Brands, which include KFC, Pizza Hut, and Taco Bell.
Vertical farming company Plenty raised a massive $400 million in Series E funding, which the company claims is the largest funding round to date for an indoor farming company. In addition, Plenty announced a strategic partnership with Walmart to supply its stores in California with its vertically farmed leafy greens.
With the promises of sustainability and technical bottlenecks to address, there are many lessons that the cellular agriculture field can learn from vertical farming companies in terms of scaling. How has vertical farming advanced in the last ten years, and what can cellular agriculture startups learn from them?
After a remarkable 2021, it was important for the year 2022 to begin strongly and carry on the cellular agriculture field’s momentum into the new year. With the first cell-based meat acquisition in the US to the largest funding round for an acellular agriculture startup in Asia, 2022 promises to be another big year for the field.
Moving forward, many themes that the field explored in 2021 will continue to advance this year as more companies look to the market. For example, both BlueNalu and Motif Foodworks highlight the importance of partnerships in commercializing cell-cultured food products.
As the year progresses, the field will see more partnerships between established companies in the food industry and cellular agriculture startups. Like Tnuva Group partnering with Pluristem Therapeutics, the field will see more corporates explore how to enter the cellular agriculture field and become part of its supply chain.
While Singapore remains the only country to give regulatory approval for the sale of cell-based meat, it’s likely that the following country to give regulatory approval will also be in Asia, either in an East Asian country like Japan or in the Gulf region of the Middle East. Like Singapore, the most appealing benefit of cellular agriculture for countries and governments in Asia is food security. Without requiring as many resources, like land and water for farming, countries that rely heavily on food imports can now produce enough food for their populations locally through building food processing and manufacturing facilities.
At the same time, more cellular agriculture companies may look to set up operations in Singapore to launch their first products. For example, considering that Perfect Day previously launched its cell-cultured dairy proteins in products in the US and Hong Kong, it’s likely that the company will look to launch in new markets like Singapore soon.
With 2022 starting with Remilk’s $120 million Series B funding round, there will likely be more sizeable investments in the field as the industry continues to grow and more companies reach their scaling milestones.
At the same time, the cellular agriculture field needs to continue to address many of its key challenges. There are still many obstacles ahead for the cellular agriculture field, from technical scaling pain points to regulatory approval. They will need to be addressed before cellular agriculture can become a viable part of our future food system.
After a record-breaking 2021, what will the cellular agriculture look like in 2022?
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